Opposing Action of Per1 and Cry2 on Target Gene Expression
نویسندگان
چکیده
*To whom correspondence should be addressed: Michelle L. Gumz, Department of Medicine, 11 Department of Biochemistry and Molecular Biology, University of Florida, 1600 SW Archer Rd 12 Box 100224. Gainesville, FL 32610, USA, Tel.: (352) 273-6887; fax: (352) 392-5465; E-mail: 13 [email protected] 14 15
منابع مشابه
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
Mounting evidence suggests that the circadian clock plays an integral role in the regulation of many physiological processes including blood pressure, renal function, and metabolism. The canonical molecular clock functions via activation of circadian target genes by Clock/Bmal1 and repression of Clock/Bmal1 activity by Per1-3 and Cry1/2. However, we have previously shown that Per1 activates gen...
متن کاملExpression of PER, CRY, and TIM genes for the pathological features of colorectal cancer patients [Retraction]
As typical clock gene machinery, period (PER1, PER2, and PER3), cryptochrome (CRY1 and CRY2), and timeless (TIM), could control proliferation, cellular metabolism, and many key functions, such as recognition and repair of DNA damage, dysfunction of the circadian clock could result in tumorigenesis of colorectal cancer (CRC). In this study, the expression levels of PER1, PER2, and PER3, as well ...
متن کاملTemporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: evidence for an internal coincidence timer.
The 24-h expression of seven clock genes (Bmal1, Clock, Per1, Per2, Cry1, Cry2, and CK1 epsilon ) was assayed by in situ hybridization in the suprachiasmatic nucleus (SCN) and the pars tuberalis (PT) of the pituitary gland, collected every 4 h throughout 24 h, from female Soay sheep kept under long (16-h light/8-h dark) or short (8-h light/16-h dark) photoperiods. Locomotor activity was diurnal...
متن کاملThe clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells
The various clock genes in normal cells, through their interaction, establish a number of positive and negative feedback loops that compose a network structure. These genes play an important role in regulating normal physiological activities. The expression of clock gene PER1 is decreased in many types of cancer. PER1 is highly correlated with the initiation and progression of cancer by regulat...
متن کاملLight-independent role of CRY1 and CRY2 in the mammalian circadian clock.
Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila, binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a role for CRYs within the clock, distinct from hypothetical photoreceptor functions. Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator dri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013